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Parallel network simulations with NEURON

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The General Neural Simulation System (GENESIS) was first released for general use in 1988 as part of the first Methods in Computational Neuroscience Meeting at the Marine Biological Laboratory in Woods Hole, Mass. Since its release 19 years ago, GENESIS has provided one of the foundations for the ongoing course in Woods Hole, as well as courses offered by the European Union, courses in Mexico, Brazil, and India and soon in Japan, At last count GENESIS has also provided support for courses in at least 49 universities around the world where it has been used both as an instruction tool in realistic modeling of the nervous system, and as a simulation based tool for neurobiological education in general. The Book of GENESIS [1], which was designed to support both computational and neurobiological instruction has sold more than 6000 copies worldwide. This substantial support for the use of GENESIS in instruction has also provided the base for extensive and growing use of this software system in biological research providing the foundation for literally hundreds of peer reviewed scientific papers.

From the outset, the design of GENESIS has been premised on the assumption that advancement in understanding neural function requires the ability to build computer models based on the actual anatomy and physiology of the neurvous system itself [2]. GENESIS was the first broad scale modeling system in computational biology to encourage modelers to continue to develop and share model features and components. At the same time, the GENESIS project was involved in proposed technological standardization efforts for testing simulation performance and sharing of neuronal models (the Rall packs and NeuroML).


  title={{Parallel network simulations with NEURON}},
  author={Migliore, M. and Cannia, C. and Lytton, W.W. and Markram, H. and Hines, M.L.},
  journal={Journal of Computational Neuroscience},