Medications

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We get the impression that many people are skeptical about the effectiveness of medications for improving digestion, reducing bile, etc. Some of the options include:

  • GATTEXX: a glucagon-like peptide (teduglutide) that stimulates the repair and regeneration of cells lining the intestine, and seems to be producing pretty impressive results in phase 3 clinical trials
  • Acid reflux medications: Ranitidine (zantac) can be added to TPN. Protonix, Prevacid, Prilosec, and Nexium are proton pump inhibitors that can be taken orally or by g-tube. Protonix is available in IV form, but this is not compatible with TPN.
  • ursodiol (brand name actigall): is supposed to increase movement of bile out of the liver and into the intestines . (I think) This drug is prescribed because doctors have seen good results. Can be given orally or IV.
  • Imodium: is supposed to reduce transit time of food through the intestines. Some doctors are believers some are not.
  • mucomyst: used as anti toxin to keep the liver healthy from TPN damage -- some parents are big fans, but this medication can be hard to get because it is not well known. The (first?) published paper reports positive effects in 3 case studies, in the Journal of Pediatric Gastroenterology and Nutrition: Image:Pdf_icon.png Jpgn_paper_2008.pdf‎
  • Reglan: Used to treat reflux and increase motility. Can be given orally or IV. Used as a last resort due to side effects?
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